FIT FOR USE ASSESSMENT OF BIOZEN AS A BIOMETRIC SENSOR CONCENTRATOR FOR REMOTE PATIENT MONITORING

In recent years, COVID-19 highlighted the importance of virtual health solutions with regard to improving patient health and conserving valuable hospital resources. Currently, the Defense Health Agency (DHA) does not own a remote patient-monitoring solution and relies on external commercial entities to provide the application and services. This could potentially lead to the DHA not retaining complete data ownership when patient data would reside on or traverse through commercial remote patient-monitoring solutions. This thesis evaluates BioZen, a DHA-owned biomedical sensor concentrator designed to run on a mobile phone, as a remote patient-monitoring tool. From this analysis, several key measures of effectiveness and measures of performance for remote patient-monitoring tools are identified and operationalized to measure the overall value BioZen brings to the DHA. Based on this research, it was found that the current build of BioZen, 2.0.0, is unable to meet any of the measures outlined in the study as a remote patient-monitoring tool. A future build of BioZen, or any remote patient-monitoring tool, could then be assessed using the measures of effectiveness and measures of performance within this study to determine the overall value brought to the DHA.Defense Health Agency, 7700 Arlington Boulevard, Falls Church, VA 22042Captain, United States ArmyLieutenant, United States NavyApproved for public release. Distribution is unlimited

Dual Hypocretin Receptor Antagonism Is More Effective for Sleep Promotion than Antagonism of Either Receptor Alone

The hypocretin (orexin) system is involved in sleep/wake regulation, and antagonists of both hypocretin receptor type 1 (HCRTR1) and/or HCRTR2 are considered to be potential hypnotic medications. It is currently unclear whether blockade of either or both receptors is more effective for promoting sleep with minimal side effects. Accordingly, we compared the properties of selective HCRTR1 (SB-408124 and SB-334867) and HCRTR2 (EMPA) antagonists with that of the dual HCRTR1/R2 antagonist almorexant in the rat. All 4 antagonists bound to their respective receptors with high affinity and selectivity in vitro. Since in vivo pharmacokinetic experiments revealed poor brain penetration for SB-408124, SB-334867 was selected for subsequent in vivo studies. When injected in the mid-active phase, SB-334867 produced small increases in rapid-eye-movement (REM) and non-REM (NR) sleep. EMPA produced a significant increase in NR only at the highest dose studied. In contrast, almorexant decreased NR latency and increased both NR and REM proportionally throughout the subsequent 6 h without rebound wakefulness. The increased NR was due to a greater number of NR bouts; NR bout duration was unchanged. At the highest dose tested (100 mg/kg), almorexant fragmented sleep architecture by increasing the number of waking and REM bouts. No evidence of cataplexy was observed. HCRTR1 occupancy by almorexant declined 4–6 h post-administration while HCRTR2 occupancy was still elevated after 12 h, revealing a complex relationship between occupancy of HCRT receptors and sleep promotion. We conclude that dual HCRTR1/R2 blockade is more effective in promoting sleep than blockade of either HCRTR alone. In contrast to GABA receptor agonists which induce sleep by generalized inhibition, HCRTR antagonists seem to facilitate sleep by reducing waking “drive”

Diversidade de Pentatomoidea (Hemiptera, Heteroptera) em três fragmentos de Mata Atlântica no sul de Santa Catarina

A composição e a variação sazonal da fauna de Pentatomoidea (Hemiptera) foi avaliada entre setembro de 2005 e agosto de 2006 em três fragmentos de Mata Atlântica na região sul de Santa Catarina (Brasil): Parque Ecológico José Milanese (Criciúma, 28º41'23''S, 49º25'55''W), Parque Ecológico de Maracajá (Maracajá, 28º52'51''S, 49º27'59''W) e Balneário Morro dos Conventos (Araranguá, 28º56'05''S, 49º21'47''W). Foram realizadas coletas mensais ao longo de trilhas nas três áreas, utilizando guarda-chuva entomológico e rede de varredura para amostrar nas bordas de mata. Para um esforço amostral de 108 horas foram coletados 595 indivíduos, distribuídos em 4 famílias, 29 gêneros e 49 espécies. Pentatomidae foi a família mais abundante (82,69%) seguida de Cydnidae (15,97%), Scutelleridae (0,84%) e Tessaratomidae (0,50%). Pentatomidae também apresentou a maior riqueza com 37 espécies. As espécies mais abundantes foram Mormidea notulifera Stål, 1860, Oebalus ypsilongriseus (De Geer, 1773), Arvelius albopunctatus (De Geer, 1773), Edessa subrastrata Bergroth, 1891, Galgupha schulzii (Fabricius, 1781) e Agroecus scabricornis (Herrich-Schäffer, 1844). O período de maior captura foi entre o final da primavera e início do outono, representando 71,76% do total coletado. O Parque do Maracajá apresentou abundância e riqueza sgnificativamente maiores do que as demais áreas. Este estudo representa o primeiro inventário da diversidade de Pentatomoidea em habitats naturais no estado de Santa Catarina